Keeping with tradition, 2021 Topps Update Series Baseball was the final flagship release of the collecting year. The base set checklist is composed of 330 cards and includes traded players in their new uniforms, rookies who made their debut later in the season, and a variety of season highlight cards that cover the 2021 campaign. Although they are not as prevalent as in other Topps Baseball products, autograph and relic cards can be found in the set.

The 2021 Topps Update Series Baseball Hobby Box comes with 14 cards per pack, and 24 packs per box. On average, each hobby box holds one autograph or relic card and one Silver Pack that contains Chromium Mojo parallels that utilize the 1985 Topps Baseball card design.

The 2021 Topps Update Series Baseball Hobby Box was released on October 29th, 2021.